Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 67, Pages 7442-7444Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc44508a
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Funding
- Health Labour Sciences Research Grant (Research on Publicly Essential Drugs and Medical Devices) from the Ministry of Health, Labour and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT) [21300190, 23650288]
- MEXT [23800045]
- Grants-in-Aid for Scientific Research [23650288, 23800045, 25870392, 21300190] Funding Source: KAKEN
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Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.
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