Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 81, Pages 9305-9307Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45696j
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Funding
- Russian Foundation Basic Research [13-03-003004]
- US National Institute of General Medical Sciences [P20GM103451]
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3-Substituted 2-quinolones are obtained via a novel, metal-free transannulation reaction of 2-substituted indoles with 2-nitroalkenes in polyphosphoric acid. The reaction can be used in conjunction with the Fisher indole synthesis offering a practical three-component heteroannulation methodology to produce 2-quinolones from arylhydrazines, 2-nitroalkenes and acetophenone.
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