4.7 Article

ATRP synthesis of poly(2-(methacryloyloxy)ethyl choline phosphate): a multivalent universal biomembrane adhesive

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 61, Pages 6831-6833

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41895b

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Funding

  1. CIHR
  2. Canadian Blood Services
  3. Health Canada
  4. CFI
  5. Michael Smith Foundation for Health Research (MSFHR)
  6. MSFHR

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A new monomer, 2-(methacryloyloxy)ethyl choline phosphate, and its direct polymerization into a polyvalent choline phosphate are described, providing a universal biomembrane adhesive exhibiting rapid, strong attachment to any mammalian cell membrane and fast internalization, properties of great value in applications such as tissue engineering and drug delivery.

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