4.7 Article

Pyrene-imidazolium complexed graphene for the selective fluorescent detection of G-quadruplex forming DNA

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 99, Pages 11698-11700

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc46744a

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Funding

  1. NRF [2012R1A4A1027750, 2012-002547]
  2. Next-Generation BioGreen 21 Program (SSAC), Rural Development Administration, Korea [PJ009041022012]
  3. Rural Development Administration (RDA), Republic of Korea [PJ009041022012] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A unique system has been developed for quantifying G-quadruplex forming DNA down to picomolar levels for future applications in telomeric assessment. Pyrene-imidazolium captured in high amounts on the surface of reduced graphene oxide shells allows specific DNA sequence detection by complex formation resulting in release and fluorescence enhancement of pyrene-imidazolium.

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