Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 80, Pages 9155-9157Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc44880k
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Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity.
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