4.7 Article

A new strategy for designing a graphene oxide-based DNA hairpin probe: fluorescence upon switching the orientation of the sticky end

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 84, Pages 9827-9829

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45307c

Keywords

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Funding

  1. National Natural Science Foundation of China [21190044, 21205032, 91027000]
  2. National Natural Science Foundation of Postdoctoral Scientists of China [2013M531779]
  3. National Basic Research Program [2011CB911002]
  4. International Science & Technology operation Program of China [2010DFB30300]
  5. Hunan Provincial Natural Science Foundation of China [13JJ4032]

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Here we report a new strategy for designing a graphene oxide (GO)-quenched dye-labeled DNA hairpin probe by utilizing the sticky end adsorbed onto the GO surface. Only introduction of target DNA can alter the orientation of the sticky end, causing the dye to move apart from the GO surface, resulting in fluorescence restoration.

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