Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 66, Pages 7286-7288Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc43334j
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Funding
- National Natural Science Foundation of China [20974052]
- PCSIRT [IRT1257]
- National Key Technologies R&D Program for New Drugs of China [2012ZX09301-003-001]
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Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.
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