4.7 Article

A difunctional DNA-AuNP dendrimer coupling DNAzyme with intercalators for femtomolar detection of nucleic acids

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 66, Pages 7304-7306

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc43205j

Keywords

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Funding

  1. National 973 Basic Research Program of China [2010CB732403]
  2. NSFC of China [41176079, 21075019]
  3. Doctoral Program of Higher Education of China [20103514120003]
  4. NSF of Fujian Province [2011J06003]
  5. Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]

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A novel difunctional DNA-nanogold (AuNP) dendrimer with a hemin-G-quadruplex was for the first time utilized as the nanotag for the in situ amplified electronic signal for nucleic acid detection by coupling high efficiency DNAzyme with the intercalated methylene blue (MB).

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