4.7 Article

A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 35, Pages 3655-3657

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc39067e

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Funding

  1. Spanish CICYT [CTQ2007-63690/BQU]
  2. MEC (Spain)

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The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M: L is 1: 1 (M=Co(II) or Fe(III)) at pH 5.5-7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.

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