4.7 Article

Resonance Raman scattering of catalytic beacons for DNA detection

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 31, Pages 3206-3208

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc40346g

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Funding

  1. EPSRC
  2. Royal Society

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A novel method for analysing the catalytic action of a DNAzyme is reported. Resonance Raman scattering (RRS) is shown to successfully monitor the oxidation of two different peroxidase substrates and has been implemented in an assay for the detection of target DNA, providing a more sensitive method of analysis than current colorimetric techniques.

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