4.7 Article

Serum albumin enhances the membrane activity of ZnO nanoparticles

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 39, Pages 4172-4174

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc37871c

Keywords

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Funding

  1. Nuffield Foundation [URB/39543]
  2. Biomedical and Health Research Centre at the University of Leeds
  3. ENNSATOX programme
  4. EU [NMP-229244]
  5. EPSRC [EP/K03135X/1, EP/E059678/1] Funding Source: UKRI
  6. Engineering and Physical Sciences Research Council [EP/E059678/1, EP/K03135X/1] Funding Source: researchfish

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We investigate the effect of serum albumin on the interaction of ZnO nanoparticles with DOPC lipid membranes and show that the size-stabilizing effect of the protein corona enhances their interaction with lipid membranes, which manifests, in part, as an increased ordering in the lipid packing.

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