☆ 4.7 Article

Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity

CHEMICAL COMMUNICATIONS (2013)

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Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 47, Pages 5423-5425

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc40953h

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Categories

Chemistry, Multidisciplinary

Funding

  1. University Grants Committee (Area of Excellence Scheme) of the Hong Kong Special Administrative Region of China [AoE/P-03/08]
  2. National Key Basic Research Program of China [2013CB834802]
  3. University Grants Committee of the Hong Kong Special Administrative Region of China [SEG_HKU02]

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A panel of luminescent platinum(II) complexes containing bidentate N-heterocyclic carbene ligands selectively localize to the endoplasmic reticulum (ER) domain, induce ER stress and cell apoptosis. Some of them show potent photo-toxicity to cancer cells.

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