Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 15, Pages 1521-1523Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc38944d
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Funding
- EPSRC [EP/J007455/1]
- AstraZeneca
- Royal Society
- Engineering and Physical Sciences Research Council [EP/K03927X/1, 1100702, EP/J007455/1] Funding Source: researchfish
- EPSRC [EP/K03927X/1, EP/J007455/1] Funding Source: UKRI
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We report efficient Pd-catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes as the basis of a general entry to alpha,alpha-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.
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