4.7 Article

An ultrasensitive electrochemical aptasensor with autonomous assembly of hemin-G-quadruplex DNAzyme nanowires for pseudo triple-enzyme cascade electrocatalytic amplification

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 66, Pages 7328-7330

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc42874e

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Funding

  1. NNSF of China [21275119, 21075100]
  2. State Key Laboratory of Electroanalytical Chemistry [SKLEAC2010009]
  3. Ministry of Education of China [708073]
  4. Postgraduate Science and Technology Innovation Program of Southwest China University [KB2010006]

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We for the first time fabricate a pseudo triple-enzyme cascade electrocatalytic electrochemical aptasensor by using the alcohol dehydrogenase (ADH) as well as the autonomously assembled hemin-G-quadruplex that simultaneously acted as an NADH oxidase and HRP-mimicking DNAzyme.

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