Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 90, Pages 10641-10643Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc43844a
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Funding
- NSF of China [21202048]
- Program for Minjiang Scholar [10BS216]
- Science Research Item of Science and Technology of Xiamen City [3502z201014]
- Fundamental Research Funds of Huaqiao University
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A convenient one-pot weak base-promoted synthesis of polysubstituted pyrroles has been developed from benzylamines and ynones. This transformation involves the Michael addition reaction and intramolecular condensation, which features high regioselectivity, high efficiency, environmental friendliness and metal free. A series of polysubstituted pyrroles were provided in up to 91% yield for 27 examples.
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