Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 55, Pages 6212-6214Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc42791a
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Funding
- National Science Council [100-2113-M007-018-MY2]
- Ministry of Education, Taiwan (ROC) [101N2011E1]
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A general approach to mimic the sensing scheme of allosteric enzymes is developed. Through the covalent labeling of a sulfonamide inhibitor to the enzyme HCAII via SNAP-tag protein, the enzyme is rendered inactive. Catalytic activation is triggered only when a protease is present to cleave the recognized peptide sequence.
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