4.7 Article

Three-component reaction of small-ring cyclic amines with arynes and acetonitrile

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 58, Pages 6558-6560

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc42854k

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Funding

  1. Welch Foundation [AX-1788]
  2. Max and Minnie Tomerlin Voelcker Fund
  3. San Antonio Life Sciences Institute (SALSI)
  4. University of Texas at San Antonio

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A novel stereospecific three-component reaction of aziridines and azetidines with arynes and acetonitrile has been developed. The reaction affords N-aryl gamma-aminobutyronitriles and delta-aminovaleronitriles that can be used as precursors and congeners of a number of bioactive compounds, such as pregabalin and lergotrile.

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