4.7 Article

A highly sensitive near-infrared fluorescent probe for cysteine and homocysteine in living cells

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 80, Pages 9176-9178

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45519j

Keywords

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Funding

  1. 973 Program [2013CB933800]
  2. National Natural Science Foundation of China [21227005, 21035003, 21275092]
  3. Key Natural Science Foundation of Shandong Province of China [ZR2011BZ006]
  4. Specialized Research Fund for the Doctoral Program of Higher Education of China [20113704130001, 20123704110004]
  5. Program for Changjiang Scholars and Innovative Research Team in University

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A near-infrared fluorescent probe (Cy-O-CHO) for the detection of endogenous Cys/Hcy in living cells was designed and synthesized. Cy-O-CHO exhibited high sensitivity and good selectivity to Cys/Hcy under physiological conditions with a detection limit of 7.9 nM for Cys.

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