4.7 Article

A gold(III) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 39, Pages 4364-4366

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc37366a

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Funding

  1. Area of Excellence Scheme [AoE/P-10/01]
  2. Innovation and Technology Fund [ITS/134/09FP]
  3. General Research Fund [HKU 704812P]

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A cytotoxic gold(III) complex of meso-tetraphenylporphyrin ([Au(TPP)]Cl, denoted gold-1a) blocks the self-renewal ability of cancer stem-like cells and shows appealing safety pharmacological profiles in rodents.

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