4.7 Article

Cyclometalated iridium(III) polypyridine dibenzocyclooctyne complexes as the first phosphorescent bioorthogonal probes

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 39, Pages 4271-4273

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36907a

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Funding

  1. Hong Kong Research Grants Council [CityU 102212, CityU 102410]
  2. Outstanding Academic Performance Award
  3. City University of Hong Kong

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We report the synthesis, photophysical behavior, and biological properties of new cyclometalated iridium(III) polypyridine complexes appended with a dibenzocyclooctyne (DIBO) moiety; these complexes have been utilized as the first phosphorescent bioorthogonal probes for azide-modified biomolecules.

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