Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 81, Pages 9254-9256Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45353g
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Funding
- Swiss National Science Foundation [315230-125483]
- European Research Council starting grant [243182]
- Human Science Frontiers [RGY0023]
- European Research Council (ERC) [243182] Funding Source: European Research Council (ERC)
- Swiss National Science Foundation (SNF) [315230_125483] Funding Source: Swiss National Science Foundation (SNF)
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Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated pre-synaptic protein alpha-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.
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