Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 13, Pages 1303-1305Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc38570h
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Funding
- National Research Foundation (NRF [2012R1A2A1A01002881, 2008-05943, MRC (2011-0030738), WCU (R32-10084)]
- KNIH ROAD R&D Program Project [A092058]
- NRF [2011-0028663, 2011-0022978]
- Ajou university
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We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to A beta plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual A beta plaque in living transgenic mice at more than 380 mu m depths.
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