Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 96, Pages 11293-11295Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45914d
Keywords
-
Categories
Ask authors/readers for more resources
The visualization of Golgi glycosylation defects in patients' cells with Congenital Disorders of Glycosylation (CDG) is challenging and necessitates the use of cumbersome glycan analysis methods that are barely adapted to clinical research. We show here that metabolic labelling of patient cells with alkyne-tagged sialic-acid (SiaNAl) enables an easy and reliable readout assay for the detection of CDG occurrence. It also provides valuable clues regarding the pathological processes by assessing the distribution of sialic acid analogues within the cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available