4.7 Article

In vitro and in vivo imaging application of a 1,8-naphthalimide-derived Zn2+ fluorescent sensor with nuclear envelope penetrability

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 97, Pages 11430-11432

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc46862c

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Funding

  1. National Basic Research Program of China [2011CB935800]
  2. National Natural Science Foundation of China [21271100, 21131003, 21021062, 91213305]

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A newly developed fluorescent sensor, Naph-BPEA, shows a specific turn-on response to Zn2+ and can be excited by visible light. The in situ nuclear Zn2+ imaging in HeLa and HepG2 cells reveals the nuclear envelope penetrability of the sensor. The specific sensor location in a zebrafish larva was also demonstrated.

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