Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 89, Pages 11023-11025Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36341k
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Funding
- Chinese Academy of Sciences
- National Natural Science Foundation of China [21002106, 21133011]
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A novel and efficient double-carbonylation of indoles with primary or secondary amines to yield indole-3-alpha-ketoamides has been developed and bioactive molecules could be one-pot synthesized using the current methodology, which could also be selectively switched to mono-carbonylation to afford indole-3-amides only by a slight modification of reaction conditions.
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