Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 26, Pages 3236-3238Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17859a
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Funding
- Cultivation Foundation for the New Faculties from Tianjin University [60302010]
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An atom economical synthesis of isoquinolinones and analogues via ligand-free Pd-catalysed C-H and N-H double activation has been developed. A series of isoquinolinones were obtained in good to excellent yields. Good regioselectivities were also observed during the activation reactions with unsymmetrical alkynes. A practical one-pot procedure for the preparation of N-H isoquinolinones is also described.
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