Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 17, Pages 2331-2333Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17496k
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Funding
- National Research Foundation of Korea (NRF) [NRF-2009-0078236, NRF-2011-355-C00047]
- Chemical Genomics grant [M105260200 02-08N2602-00210]
- World Class University
- BK21 Scholarship
- Seoul Science Fellowship
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We developed a novel fluorescent bioprobe (SF44) that can specifically visualize the cellular lipid droplets in in vitro and in vivo systems and illustrated the mechanistic rationale of its fluorogenic property. Its application to image-based high throughput screening led us to the identification of a new small-molecule modulator of lipid droplet formation.
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