4.7 Article

The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 64, Pages 8003-8005

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc33200k

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Funding

  1. National Natural Science Foundation of China [20932003, 90813012]
  2. Ministry of Science and Technology of China [2012ZX09504-001-003]
  3. Fundamental Research Funds for the Central Universities [lzujbky-2010-126]

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The first asymmetric aza-Friedel-Crafts reaction of indoles and pyrroles with isatin-derived N-Boc ketimines catalyzed by chiral phosphoric acids is reported. In general, derivatives of substituted 3-amino-2-oxindoles were obtained with excellent enantioselectivities and high yields.

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