4.7 Article

A turn-on fluorescent probe based on hydroxylamine oxidation for detecting ferric ion selectively in living cells

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 43, Pages 5310-5312

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31426f

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Funding

  1. National Natural Science Foundation of China [20975089, 20833008]
  2. NKBRSF [2007CB815202]
  3. Chinese Academy of Sciences [KZCX2-EW-206]

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We have described a turn on fluorescent probe BOD-NHOH based on hydroxylamine oxidation for detecting intracellular ferric ions. The probe comprises a signal transducer of BODIPY dye and a Fe3+-response modulator of hydroxylamine. It is readily employed for assessing intracellular ferric ion levels, and confocal imaging is achieved successfully.

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