4.7 Article

A one-pot'' multicomponent approach to polysubstituted 4-aminopyridines

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 22, Pages 2785-2787

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17850h

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Funding

  1. National Science Foundation of China [81072516]
  2. Natural Science Foundation of Zhejiang Province [Z2110655]

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A novel and facile domino reaction has been developed to synthesize a variety of polysubstituted 4-aminopyridines from alpha-azidovinylketones, aldehydes and methylamine derivatives in reasonably good yields under mild conditions. Additionally, a possible mechanism is proposed.

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