4.7 Article

Solvent dependence of helix stability in aromatic oligoamide foldamers

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 51, Pages 6337-6339

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31533e

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Funding

  1. FP7 Marie Curie Post-Doctoral Fellowship [PIIF-2009-254156]
  2. CNRS-JSPS
  3. Grants-in-Aid for Scientific Research [09F09247] Funding Source: KAKEN

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A new helical aromatic oligoamide foldamer, bearing triethyleneglycol side chains for solubility in a broad range of media, was prepared. The stability of the helical conformation was assessed in various solvents and shown to vary greatly and unexpectedly. Stability was remarkably enhanced in methanol-water mixtures.

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