4.7 Article

An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 57, Pages 7164-7166

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc33089j

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Funding

  1. Zhejiang Natural Science Fund [Y2080303]

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We report the design and synthesis of a new class of fluorogenic probes based on monoamine oxidase-triggered oxidative C-O bond cleavage. The selectivity of probe P1 towards MAO-B was 22-fold higher than that towards MAO-A.

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