4.7 Article

Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 39, Pages 4767-4769

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc30730h

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Funding

  1. National Institute of General Medical Sciences [R00 GM092970]
  2. University of Oregon (UO)
  3. [CHE-0923589]
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R00GM092970] Funding Source: NIH RePORTER

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Hydrogen sulfide (H2S) is an important biological messenger but few biologically-compatible methods are available for its detection. Here we report two bright fluorescent probes that are selective for H2S over cysteine, glutathione and other reactive sulfur, nitrogen, and oxygen species. Both probes are demonstrated to detect H2S in live cells.

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