4.7 Article

A highly selective fluorescent probe for fast detection of hydrogen sulfide in aqueous solution and living cells

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 88, Pages 10871-10873

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36141h

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Funding

  1. National Basic Research Program of China (973 Program) [2010CB126100]
  2. National High Technology Research and Development Program of China (863 Program) [2011AA10A207]
  3. China 111 Project [B07023]
  4. Shanghai Leading Academic Discipline Project [B507]

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A new ratiometric fluorescence probe E1 based on an excited-state intramolecular proton transfer (ESIPT) mechanism for detection of hydrogen sulfide (H2S) is reported. E1 responds to H2S quickly and showed a 30-fold fluorescence enhancement in 2 minutes. Moreover, E1 can detect H2S quantitatively with a detection limit as low as 0.12 mu M in aqueous solution. Its potential for biological applications was confirmed by employing it for fluorescence imaging of H2S in living cells.

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