4.7 Article

Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 6, Pages 835-837

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc16178d

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Funding

  1. Ministry of Education [R-143-000-394-112]
  2. Agency for Science, Technology and Research (A*Star) [R143-000-391-305]
  3. National Research Foundation (NRF) [NRF-G-CRP 2007-04]
  4. Singapore National Research Foundation

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We report herein the design, synthesis and application of K11777-derived activity-based probes (ABPs) allowing in situ profiling and identification of potential cellular targets of K11777 in Trypanosoma brucei.

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