Journal
TRENDS IN CELL BIOLOGY
Volume 10, Issue 1, Pages 17-24Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(99)01673-6
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM052702] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM52702] Funding Source: Medline
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The kelch motif was discovered as a sixfold tandem element in the sequence of the Drosophila kelch ORF1 protein. The repeated kelch motifs predict a conserved tertiary structure, a P-propeller. This module appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this growing superfamily are present throughout the cell and extracellularly ann have diverse activities. In this review, we discuss current information concerning the structural organization of kelch repeat proteins, their biological roles and the molecular basis of their action.
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