4.7 Article

Rhodium-catalyzed oxidative C2-acylation of indoles with aryl and alkyl aldehydes

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 42, Pages 5163-5165

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31351k

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Funding

  1. National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2009ZX09102-026]

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A rhodium-catalyzed oxidative C2-acylation of indoles with aryl and alkyl aldehydes via C-H bond activation is described. The reaction is highly atom-economic and provides easy access to a wide variety of 2-aroylindoles.

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