4.7 Article

Graphene oxide-photosensitizer conjugate as a redox-responsive theranostic agent

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 79, Pages 9912-9914

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35197h

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Funding

  1. National Cancer Center [1010150-3]
  2. Fundamental R&D Program for Core Technology of Materials by the Ministry of Knowledge Economy, Republic of Korea
  3. Korea Evaluation Institute of Industrial Technology (KEIT) [K0006001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  4. Korea Health Promotion Institute [1010150-3, 1010150] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A nano-sized graphene oxide-photosensitizer conjugate with a redox-responsive cleavable disulfide linker is non-fluorescent and non-phototoxic, even upon light irradiation. It becomes highly fluorescent and phototoxic inside cancer cells, where glutathione is used as an initiator for activating the photosensitizer.

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