Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 44, Pages 5482-5484Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31537h
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Funding
- Office of Naval Research [N00014-09-1-0848]
- National Institutes of Health [R00RR024366]
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A modular system for detecting protease activity via enzyme-triggered gel formation is described. Protease-specific recognition sequences are utilized to achieve enzyme specificity. Artificial blood clotting is demonstrated by activating endogenous thrombin to trigger gelation in fibrinogen-deficient blood plasma.
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