4.7 Article

Design of chiral sulfoxide-Schiff base hybrids and their application in Cu-catalyzed asymmetric Henry reactions

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 45, Pages 5596-5598

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31907a

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Funding

  1. National Science Foundation of China [21002036]
  2. National Basic Research Program of China [2011CB808603]

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A new class of chiral sulfoxide-Schiff base ligands has been developed by the rational combination of two privileged chiral backbones. These sulfoxide-Schiff base ligands were found to be highly efficient for Cu-catalyzed asymmetric Henry reactions (up to 98% yield and 96% ee).

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