4.7 Article

GOx signaling triggered by aptamer-based ATP detection

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 74, Pages 9284-9286

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34279k

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Funding

  1. Louisiana Cancer Research Consortium
  2. NIH-RCMI from the National Institute on Minority Health and Health Disparities [5G12RR026260]
  3. NSF-SURE [EPS-0701491]

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Aptamer based ATP binding leads to the release of the co-factor FAD, which acts as a trigger to 'turn-on' the activity of apo-GOx and thus generates a measurable response.

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