4.7 Article

Sensitive point-of-care monitoring of HIV related DNA sequences with a personal glucometer

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 87, Pages 10733-10735

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35941c

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Funding

  1. National Natural Science Foundation of China [21275004, 20905062, 21075100, 21173274]
  2. Scientific Research Foundation for the Returned Overseas Chinese Scholars, Fundamental Research Funds for the Central Universities [XDJK2012A004]
  3. Southwest University [SWUB2008078]

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The hybridizations between the HIV target DNA and the capture probes as well as the signal probes conjugated to the multi-invertase/nanoparticle composites lead to the conversion of sucrose to glucose, which is monitored by the personal glucometer and provides quantitative digital readings for point-of-care diagnosis of HIV DNA fragments.

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