☆ 4.7 Article

A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes

CHEMICAL COMMUNICATIONS (2012)

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Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 34, Pages 4091-4093

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17868k

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Categories

Chemistry, Multidisciplinary

Funding

  1. NIH [R01 CA136810, R33 CA126659/CA126659Z]

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beta-ketoesters are robust probes for labeling sulfenic acid (-SOH) proteins allowing quantitative cleavage of the tag for improved analysis of the labeled peptides by MS.

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