Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 91, Pages 11181-11183Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35583c
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Funding
- Engineering and Physical Sciences Research Council [EP/E017495/1] Funding Source: researchfish
- EPSRC [EP/E017495/1] Funding Source: UKRI
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The synthesis of a second-generation [6]-helicenoidal DMAP organocatalyst is reported. The synthesis is reliant upon a highly diastereoselective Rh-catalysed [2 + 2 + 2] triyne cycloisomerization, using an existing stereocentre to control the sense of forming helicity. Taken together, a scalable (> 1 g), resolution-free entry to a helical DMAP with the capacity for subsequent functionalization, has been achieved.
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