4.7 Article

Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 13, Pages 1919-1921

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17140f

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Funding

  1. NSFC [20902025, 21172075]
  2. SMEC [12ZZ046]
  3. Shanghai Pujiang Program [10PJ1403100]
  4. 973 program [2011CB808600]

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We report the first example of highly enantioselective organocatalytic synthesis of 3-difluoroalkyl substituted 3-hydroxyoxindoles. The total synthesis of the difluoro analogue of convolutamydine E was achieved by this method.

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