Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 43, Issue 1, Pages 36-40Publisher
MUNKSGAARD INT PUBL LTD
DOI: 10.1111/j.8755-8920.2000.430107.x
Keywords
anti-cardiolipin; autoantibodies; autoimmunity; IVF failure; pregnancy rate
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PROBLEM: The study was conducted to investigate the efficacy of prednisone and aspirin in autoantibody seropositive patients with repeated in vitro fertilization-embryo transfer (IVF-ET) failure, METhODS OF STUDY: The study group comprised 52 consecutive patients seropositive for non-organ-specific autoantibodies? i.e., anti-cardiolipin antibodies (ACA), anti-nuclear antibodies (ANA). anti-double-stranded (ds) DNA, rheumatoid factor (RF), and lupus anti-coagulant (LAC). These patients were treated with prednisone, 10 mg per day, and aspirin, 100 mg per day, starting 4 weeks before induction of ovulation in 52 IVF cycles. RESULTS: The clinical pregnancy rate per cycle was 32.7% (17/52). No increased incidence of pregnancy complications. including premature labor, gestational diabetes mellitus, and pregnancy-induced of hypertension, were found. CONCLUSIONS: Combined treatment of prednisone for immunosupression and aspirin as an anti-thrombotic agent, starting before ovulation induction, may improve pregnancy rate in autoantibody seropositive patients who have had repeated IVF-ET failures.
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