Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 61, Pages 7607-7609Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc32942e
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Funding
- National Natural Science Foundation of China [21121061, 21172274]
- Doctoral Scientific Fund Project of the Ministry of Education of China [20100171110013]
- Fundamental Research Funds for the Central Universities
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Two new Pt(II) squares with quinoxaline-bridges selectively stabilize human telomeric G-quadruplexes with high binding constants (10(7)-10(9) M-1) and an unprecedented binding stoichiometric ratio of Pt(II) square/G-quadruplex (6 : 1). This selectivity is likely due to the Pt(II) squares' cube-like shape. Both Pt(II) squares also show significant telomerase inhibition and anticancer efficacy.
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