4.7 Article

Nicking enzyme based homogeneous aptasensors for amplification detection of protein

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 3, Pages 374-376

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15853h

Keywords

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Funding

  1. National Basic Research Program of China [2010CB732403]
  2. National Natural Science Foundation of China [20975023, 20735002]
  3. program for new century excellent talents in university of China [09-0014]
  4. National Science Foundation of Fujian Province [2010J06003]

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A simple and highly sensitive homogeneous aptasensor is developed, which relies on nicking enzyme. The sensitivity of this newly proposed aptasensor is about three orders of magnitude higher than that of traditional homogeneous aptasensors. Furthermore, it is capable of detecting target protein in real samples.

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