Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 45, Pages 5614-5616Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc31975f
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Funding
- EPSRC [EP/F056826/1, EP/F008597/1, EP/G004897/1, EP/F055803/1, EP/F009186/1, EP/F009062/1, EP/F056605/1, EP/I016651/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F009186/1, EP/F009062/1, EP/F055803/1, EP/F056605/1, EP/G004897/1, EP/I016651/1, EP/F008597/1, EP/F056826/1, GR/A10274/01] Funding Source: researchfish
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Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.
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