4.7 Article

A mitochondria-localized two-photon fluorescent probe for ratiometric imaging of hydrogen peroxide in live tissue

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 29, Pages 3518-3520

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc00034b

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Funding

  1. NRF [2011-0028663, 2011-0004321]
  2. Ministry of Education, Science and Technology [2011-0022978]
  3. Ajou university
  4. Ministry of Health & Welfare, Republic of Korea [A111182]

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We report a two-photon fluorescent probe (SHP-Mito) which can ratiometrically detect mitochondrial H2O2 in live cells and intact tissues at > 100 mu m depth through the use of two-photon microscopy.

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